Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions, w... https://williamh202uky9.webbuzzfeed.com/profile