At this time, There are 2 types of studies on itaconate: Irg1−/− macrophages along with the regulatory impact of itaconate derivatives. Both of these effects had been complementary and revealed the regulatory mechanisms of itaconate included alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription factor 3 (ATF3) https://elafibranor88765.ambien-blog.com/35985851/thiamet-g-fundamentals-explained