At present, There's two kinds of experiments on itaconate: Irg1−/− macrophages along with the regulatory outcome of itaconate derivatives. These two success have been complementary and disclosed the regulatory mechanisms of itaconate associated alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription factor 3 (ATF3) induction to inhibit https://jamesu000iug3.bloggip.com/profile