The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding about βarrestin2 recruitment in cellular assays, thus demonstrating signaling bias. In mice, SR-17018 stimulates GTPγS binding in brainstem and makes antinociception with potencies similar to morphine. Nonetheless, it provides significantly less respiratory suppression and mice will not build an... https://roberts173ntw5.wikicommunications.com/user