The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding over βarrestin2 recruitment in cellular assays, thereby demonstrating signaling bias. In mice, SR-17018 stimulates GTPγS binding in brainstem and generates antinociception with potencies much like morphine. However, it makes significantly less respiratory suppression and mice don't establish ant... https://margareta024mev4.salesmanwiki.com/user