How Tramadol works Tramadol works by blocking the pain signals coming from the pain and gives a euphoric feeling. It raises the level of the chemical dopamine; this is the only thing which makes Tramadol addictive. It is not a natural opioid; Tramadol is a synthetic opioid analgesic which is https://www.crunchbase.com/organization/how-to-get-tramadol-for-depression